Computational genome and epigenome research
Our research group is situated within the Department of Physics and the Bioinformatics Research Center of North Carolina State University. By synergizing simulation and data-driven approaches, we are committed to building innovative computational models to answer crucial questions in the realm of genome and epigenome.
The genome is often hailed as the blueprint of life, but the precise way this blueprint maps into different cell identities remains largely unknown. Both genome and epigenome play a pivotal role in orchestrating this mapping through the...
Epigenetic enzymes play a pivotal role in maintaining cell identities by catalyzing and distributing histone modifications, which further regulate chromatin structures. Despite decades of research, the mechanism by which epigenetic enzymes interact with chromatin to orchestrate the delivery...
Noncoding RNAs (ncRNAs) play a critical role in epigenetic regulation, occupying approximately 70% of the human genome. Recent experimental and computational progress has revolutionized our understanding of these genome “dark matters”. Many ncRNAs, especially long noncoding RNAs (lncRNAs),...
We celebrated the end of the semester with an escape room party. Thank you all for your achievements and contributions!
The Lin group received an NSF CAREER Award supporting research on epigenetic principles underlying chromatin organization and liquid-liquid phase separation.
Congratulations to our graduating undergraduate researcher, Thomas Thornton, on receiving the 2026 McCormick Award, the Department of Physics and Astronomy’s highest honor for undergraduate research! Thomas presented his award talk, titled “Structure-Based Modeling of...
