Computational genome and epigenome research
Our research group is situated within the Department of Physics and the Bioinformatics Research Center of North Carolina State University. By synergizing simulation and data-driven approaches, we are committed to building innovative computational models to answer crucial questions in the realm of genome and epigenome.
The genome is often described as the blueprint of life, yet the mechanisms by which this blueprint gives rise to distinct cell identities remain incompletely understood. The genome and epigenome jointly orchestrate this process through the precise regulation...
Protein–nucleic acid interactions regulate many essential biological processes. Accurately predicting these interactions can deepen our understanding of molecular recognition and accelerate the development of diagnostic and therapeutic technologies. Our group develops data-efficient, physics-informed AI methods that integrate biomolecular...
Noncoding RNAs (ncRNAs) play a critical role in epigenetic regulation, occupying approximately 70% of the human genome. Recent experimental and computational progress has revolutionized our understanding of these genome “dark matters”. Many ncRNAs, especially long noncoding RNAs (lncRNAs),...
Yafan Zhang attended the Intelligent Systems for Molecular Biology conference in Washington, D.C., where he was selected to give an oral presentation on our biophysics-informed, data-driven framework for predicting protein–nucleic acid binding affinities.
The Lin group received a new NSF award supporting biophysics-informed AI models for protein-nucleic acid prediction and high-affinity oligonucleotide aptamer design.
The Lin Group attended the 2026 Southeast Symposium on Genome Integrity and Chromatin Regulation at UNC Charlotte, where Rina Li presented her research and Irene Silvernail received a poster award.
